![]() ![]() Affected skin resembles an eczematous eruption.Affected skin resembles an exaggerated sunburn-type reaction.Clinical features of drug-induced phototoxicity and photoallergy Phototoxicity The clinical features of DIP depend on the specific photosensitising agent involved and the type of skin reaction it triggers (phototoxic or photoallergic). What are the clinical features of drug-induced photosensitivity? Upon subsequent re-exposure to light, an eczematous or lichen planus-like eruption that may spread beyond sun-exposed areas occurs 24–72 hours later. ![]() The initial sensitisation period typically takes 7–10 days. The key sensitising event involves the photobinding of a drug (or its metabolite) to skin biomolecules upon exposure to UVR this forms a photoallergen. PhotoallergyĪ photoallergic reaction is an immune-mediated delayed type IV hypersensitivity reaction. The resulting oxidative stress due to the formation of ROS, and direct cellular damage caused by the free radicals, manifests as an exaggerated sunburn-like reaction.
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